Dra. María Antonia Herrero Chamorro
On January 2000, Prof. Maria Antonia Herrero Chamorro began her PhD (supported by JCCM, 2 years grant + 2 years contract) in the Microwave and Sustainable Chemistry group of UCLM, working on microwave-assisted organic reactions under the supervision of Prof. Angel Diaz Ortiz. Her first predoctoral stay was on the field of NMR under the supervision of Prof. T. Claridge, at the University of Oxford. One part of the thesis was performed in a short period of time in Uppsala (Sweden) with the Dr. M. Larhed. Enclosed on the terms of her thesis, two important collaborations were executed: one with the group of Prof. F. Cossío and the other one with the pharmaceutical company Janssen Cilag, S.A. In February 2006, she obtained the European PhD degree by the UCLM. Her first postdoctoral stay (granted by JCCM) was performed on the University of Graz (Austria) under the supervision of Prof. O. Kappe with the aim of the achievement of a comprehensive and well-design study of the “microwave effect”. Her second Postdoctoral stay (granted by JCCM) was performed under the supervision of Prof. M. Prato at the University of Trieste on the design of new nanomaterials for application in medicinal chemistry and/or material science. During this second postdoctoral stay, she maintained an active colaboration with the nanochemistry group in the UCLM and once she had ended this postdoctoral stay, she joined this group, which uses microwave radiations for the activation of carbon nanostructures in solvent-free conditions, preparing multifunctional derivatives that can serve as versatile synthons in materials science and biological applications. She has authored over 35 scientific publications, some book chapters and four scientific patents. In 2010 she received the award “women for science“ by L’Oreal-UNESCO and in 2011 “Ibn Wafid de Toledo“ Price for young researchers of Castilla-La Mancha. She was selected as “Ramon y Cajal” in 2010. She was promoted to Associate Professor in 2011. In 2012, Iberdrola Fundation granted an important research line with the main topic of the integration of carbon nanomaterials in solar cells.
1. Microwave-Enhanced Reactivity of Non-Activated Dienophiles Towards Pyrazine p-Quinodimethanes. Synlett, 12, 2037-2038 (2002).
2. Enhancing stereochemical diversity by means of microwave irradiation in the absence of solvent: Synthesis of highly subtituted nitroproline esteres via 1,3-dipolar reactions. Molecular Diversity, 7, 175-180 (2003).
3. Direct Microwave Synthesis of N,N’-Diacylhydrazines and Boc-Protected Hydrazides by in situ Carbonylatinos under Air.Synlett, 13, 2335-2338 (2004).
4. Microwave irradiation as an Efficient Tool for the Generation of Nitrogen Heterocyclic o-Quinodimethanes. Synthesis of Polyheterocyclic compounds by Diels-Alder Reactions. Synlett, 4, 579-582 (2006).
5. Solvent-Free Thermal and Microwave-Assisted [3+2] Cycloadditions between Stabilized Azomethine Ylides and Nitrostyrenes. Experimental and Theoretical Study. J. Org. Chem., 72, 4343-4322 (2007).
6. Reproducibility and Scallability of Solvent-Free Microwave-Assisted Reactions: From Domestic Ovens to Controllable Parallel Applications. Comb. Chem. and High Throughput Screening, 10, 163-169 (2007).
7. Dynamic imaging of functionalised multi-walled carbon nanotube systems circulation and urine excreation,Advance Materials, 20, 225-230 (2008).
8. Cover image: Dynamic imaging of functionalised multi-walled carbon nanotube systems circulation and urine excreation. Advance Materials, 20, (2008).
9. Influence of Polarity on the Scalability and Reproducibility of Solvent-Free Microwave-Assisted Reactions. Comb. Chem. and High Throughput Screening, 14, 109-116, (2011).
10. Reversible Microwave-Assisted Cycloaddition of Aziridines to Carbon Nanotubes. J. Am. Chem. Soc., 129, 14580-14581 (2007).
11. Microwave-Induced Multiple Functionalization of Carbon Nanotubes. J. Am. Chem. Soc., 130, 8094-8095, (2008).
12. Synthesis of Dendrimer-Carbon Nanotube conjugated, Physica Status Solidi A, 1402-1407, (2008).
13. Advance in the covalent functionalization of carbon nanotubes, Molecular Crystals and Liquid Crystals, 21-32, (2008).
14. Microwave-Assisted Reactions in Heterocyclic Compounds with Applications in Medicinal and Supramolecular Chemistry. Comb. Chem. and High Throughput Screening, 10, 877-902 (2007).
15. Tissue histology and physiology following intravenous administration of different types of functionalised multiwalled carbon nanotubes, Nanomedicine, 3, 149-151, (2008).
16. Carbon Nanotube Shape and Individualization Allow Renal Excretion, Small, 4, 1130-1132, (2008).
17. Nonthermal microwave effects revisited-on the importance of internal temperature monitoring and agitation in microwave chemistry. J. Org. Chem., 73, 36-47, (2008).
18. Functionalized Carbon Nanotubes: High biocompatibility with lack of toxicity. Int. J. Nanotechnology, 8, 885-897, (2012).
19. Antitumor Activity and Prolonged Survival by Carbon Nanotube-Mediated therapeutic siRNA Silencing in a Human Lung Xenograft Model, Small, 5, 1176-1185, (2009).
20. Cover image:Cancer therapy: Small, 10/2009.
21. Synthesis and Characterization of Carbon Nanotube-Dendron Series for Efficient siRNA Delivery. J. Am. Chem. Soc.131, 9843-9848, (2009).
22. Efficient Functionalization of Carbon Nanohorns via Microwave Irradiation. JMC, 19, 4407-4413, (2009).
23. Gold Dendrimer-Encapsulted Nanoparticles as labelling Agents for Multi-Walled Carbon Nanotubes. ACS nano, 4, 905-912, (2010).
24. Versatile Microwave-Induced Reactions for the Multiple Functionalization of Carbon Nanotubes, OBC, 8, 1932-1942, 2010.
25. Synthesis and Characterization of a Carbon Nanotube-Dendron Series for Efficient siRNA Delivery, J. Am. Chem. Soc., 132, 1731-1732, 2010.
26. Hybrid Materials based on Pd nanoparticles onto carbon nanostructures for Environmentally Benign C-C coupling chemistry, Nanoscale, 2, 1390-1400, 2010.
27. Enhanced Cellular Internalisation and Gene Silencing with a series of Cationic Dendron-Multiwalled Carbon Nanotube:siRNA Complexes, FASEB J. 24, 4354-4365, 2010.
28. Highly Conductive Redox Protein-Carbon Nanotube Complex for Biosensing Applications. Adv. Func. Mat. 21, 153-157, 2011.
29. Ball Milling modification of Single-Wall Carbon Nanotubes: purification, cutting and functionalization, Small, 7, 665-674, 2011.
30. Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing, PNAS, 108, 10952-10957, 2011.
31. Chirality dependent charge transfer events in individual semiconducting single wall carbon nanotubes – (9,4), (8,6), (8,7), and (9,7), J. Am. Chem. Soc, 133, 18696-18706, 2011.
32. Few-Layer graphenes from ball-milling of graphite with melamine, ChemComm, 47, 10936-10938, 2011.
33. Carbon nanohorns functionalized with polyamidoamine dendrimers as efficient biocarrier materials for gene therapy. Carbon, 50, 2832–2844, (2012).
34. Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA. Biomaterials, 33, 8152-8159, (2012).
35. Degree of Chemical Functionalization of Carbon Nanotubes Determines Tissue Distribution and Excretion Profile.Angewandte Chemie, 124, 6495-6499, (2012).
36. In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex.Nanomedicine, 10, 1485-1494, (2012).
37. Asbestos-like pathogenicity of long carbon nanotubes can be alleviated by chemical functionalization.Angewandte Chemie. DOI: 10.1002/anie.201207664
1. Recent Advances in Covalent Functionalization and Characterization of Carbon Nanotubes, Chapter 9: Fundamentals and ApplicHandbook of Carbon Nano Materials, ISBN-13 978-981-4350-20-4, 271-324, 2011.
2. Reproducibility and scalability of Microwave-Assisted Reactions, Chapter in Fundamentals and Microwave heating (2011), ISBN-978-953-308-337-7.