Dra. Mª Victoria Gómez Almagro

 

MVGomezMaria Victoria Gómez Almagro was born the 14th January 1978 in Ciudad Real (Spain). In July 2001, she obtained her degree in Chemistry with an honour additional at the University of Castilla-La Mancha (UCLM). Having finished her degree, she joined to the group of Prof. George Fleet from Oxford University (UK) under the supervision of Dr. Tim Claridge for a few months, giving her an intimate knowledge of the NMR spectroscopy on Synthetic Peptides. In January 2002, she started as a Ph.D candidate (Ministerio de Educación y Ciencia fellowship) at the Faculty of Chemistry (UCLM) under the supervision of Dr. Andres Moreno and Prof. Antonio de la Hoz. She has investigated the application of Microwave Irradiation as alternative and environmentally friendly energy source in the development of chemical processes. A stay of a few months at the Instituto de Tecnologia Química de Valencia (Spain), under the supervision of Prof. Avelino Corma, gave her a wider vision of the effects of the zeolite structure on the chemical processes mentioned above. In February 2006, she got her PhD degree, getting the grade of Chemistry European Doctor (cum Laude). She spent more than two years (August 2006-November 2008) at the Supramolecular Chemistry and Technology group of Prof. David Reinhoudt (University of Twente, The Netherlands) as postdoc researcher- Marie Curie Intraeuropean Fellowship (EIF) -, at the NMR & MS department under the supervision of Dr. Aldrik Velders. The Project involved the research, design and development of NMR probes with microfluidic and nanofluidic components. In February 2009, she continued her research at the Instituto Regional de Investigación Cientifica Aplicada (IRICA) (UCLM) , and focused mainly on the development of a project awarded by the European Commission -Marie Curie Reintegration program (ERG) – with title “On-line monitoring of microwave-assisted chemical reactions by rf-microcoils“. In March 2011, she started as Senior Researcher INCRECYT, within a research program from the Albacete Science and Technology Park, at the IRICA where she supervised 2 PhD projects within the group (Antonio Rodriguez and Alberto Juan) and within the topic of small-volume NMR spectroscopy with the use of radiofrequency microcoils. Since April 2015, she continues her research projects as Ramon y Cajal researcher within the same group, supervising the PhD thesis of Rosa Maria Sanchez and Jose Miguel Mateo.

Research activities.

Radiofrequency microcoils represent an efficient and cheap alternative to enhance the sensitivity of NMR for mass-limited samples. For a constant length-to-diameter ratio, the sensitivity of an NMR coil is inversely proportional to its diameter. It also means that when the detection coil is miniaturized, the sample volume can be brought down to the nanoliter regime. In our research, we are focused on the use of planar spiral microcoils integrated on top of a glass substrate (NMR-chip (figure)) for the optimization of continuous-flow chemical processes when the detection volume is in the nanoliter regime. This research topic is developed in collaboration to Prof. Dr. Aldrik Velders from University of Wageningen.

NMR-chip

Thus, Antonio M. Rodriguez  was focused on the development of methodologies for kinetic studies and monitorization of processes by combining NMR microcoils with continuous flow microreactors, while Alberto Juan developed his research on the development of methodologies and setups for the analysis of continuous flow photo-assisted reactions by NMR-microcoils. Traditional methods to optimize reaction conditions are not adequate because they require stopping the reaction and usually the time required for analysis is longer than the reaction time itself. Therefore, the use of an NMR-chip hyphenated to any type of reactor when the whole system works on continuous flow enables the monitoring of the reaction progress and the optimization of the reaction conditions in short time, with very small reaction volume and consuming very low energy.

In December 2014, Rosa M. Sanchez Donoso and Jose Miguel Mateo Gonzalez started their PhD projects within the field of NMR-microcoils. They work in the design of new NMR microcoils together with the development of new methologies for the study of certain protein surfaces. This is the main goal of the National Project awarded t0 Dr. Gómez and her research team (2015-2018).

NMR spectroscopy as a tool for the investigation of different phenomena.

NMR spectroscopy is our tool of research to study different phenomena within the group and in collaboration with other research groups (from University of Texas, University of Zaragoza, University of Castilla-La Mancha, University of Twente). The research is related to four main different fields: (Photo)- Flow Chemistry, Food science, Reaction monitoring, Materials Science, Supramolecular Chemistry and metabolomics:

NMR can be used as the main technique to provide structural information about unknown compounds in a mixture or about the structural characterization of an isolated compound, i.e. a natural product isolated from a foodstuff. NMR is applied in this sense for the structural determination of compounds like flavonol 3-O-Glycosides of red grape; Peonidin 3,7-O-β-Diglucoside and other unusual anthocyanins isolated from Garnacha Tintorera (Vitis vinifera L.) Grapes; 10-Acetyl-pyranoanthocyanins, interesting natural products found in red wines and/or grapes. In addition,  we also use NMR spectroscopy to study a certain behavior within a reaction media like for example the tendency of some compounds to form supramolecular structures maintained by non-covalent bonds, the study of the size of these architectures, the supramolecular stability in different reaction media, the location of nanoparticles encapsulated within a macromolecule, and the size of metal nanoparticles.  To reach that goal, we carry out NMR experiments like PFGSE experiments, in addition to the above mentioned experiments, which resulted very appropriate and provide detailed information on molecular structure at the atomic level. A different approach in the use of  NMR spectroscopy is in metabolomics. There, the metabolites extracted from cells are studied under a given set of conditions to gain insight into changes in cell metabolism after addition of a certain treatment. In this sense, we collaborate with the Faculty of Medicine (UCLM) in the search of a new strategy, by using the antioxidant CoQ, to sensitize glioblastoma cells to the effect of chemotherapeuticals in central nervous system tumors. In relation with this last project, we had in the group the PhD defense of Maria Moreno.

MariaVictoria.Gomez@uclm.es / Edificio Marie Curie – Avda. Camilo José Cela s/n – 13071 Ciudad Real /

Tfno. 926295300 Ext. 6732

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