Prof. Dr. Antonio de la Hoz Ayuso

Antonio de la Hoz is Professor in Organic Chemistry in the University of Castilla-La Mancha. He obtained his Ph. D. from the Universidad Complutense in Madrid in 1986 under the supervision of Prof. José Elguero and Carmen Pardo. After postdoctoral research in 1987 with Prof. Mikael Begtrup at the Danmarks Tekniske Høskole he joined the Faculty of Chemistry of the Universidad de Castilla-La Mancha in Ciudad Real in 1988 as an Assistant Professor. In 1993 he worked under the supervision Prof. André Loupy in the Université de Paris-Sud in Microwave Assisted Organic Chemistry. Prof. de la Hoz has authored over 170 scientific publications 100 of them related to Microwaves in Organic Synthesis. Dr. de la Hoz has been a foundation member of the Spanish Green Chemistry Network. His current research interests focus on Green methodologies, microwave activation, mechanochemistry, flow methodologies and solvent-free reactions, and the applications of heterocyclic compounds in material and supramolecular chemistry.

Research activities and interests

Development of devices and processes with Green methodologies and conditions: Microwave irradiation, Flow reactions, mechanochemistry




Synthesis of new materials in the frame of Green Chemistry
Dra. Pilar Prieto Nuñez Polo
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Computational Chemistry

Organic Chemistry Professor – INORGANIC, ORGANIC AND BIOCHEMISTRY DEPARTMENT /  Avda. Camilo José Cela, 10 – 13071 Ciudad Real

Web: / Tfno. 926295411 / Fax: 902 204 130

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Green synthesis of Triazine derivatives with luminiscent properties



Carbon Nanostructures and Applications. MSOC-Nanochemistry
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Lab-on-a-chip (NMR microcoils and microfluidics)

Microwaves in Organic Synthesis. Third edition. WILEY. 3-527-33116-6

Publications (2012-2008)



Cross-coupling in flow using supported catalysts: Mild, clean, efficient and sustainable Suzuki–Miyaura coupling in a single pass. J. M. Muñoz, J. Alcázar, A. de la Hoz, A. Díaz-Ortiz.Ad. Synth. Catal. Aceptado.

Sustainable and efficient methodology for CLA synthesis and identificationM. Moreno ,  M. V. Gómez ,  C. Cebrián ,  P. Prieto,  A. de la Hoz, A. Moreno. Green Chem., 2012, 14, 2584-2594

Selectivity under the action of microwave irradiation. In Microwaves in Organic Synthesis. Third Edition. A. de la Hoz, A. Díaz-Ortiz, J.R. Carrillo, M.A. Herrero. Eds. A. de la Hoz, A. Loupy Wiley (Weinheim) ISBN 3-527-33116-6 (in press).

Elucidation of microwave effects: Methods, theories and predictive models. In Microwaves in Organic Synthesis. Third Edition. A. de la Hoz, A. Díaz-Ortiz, A. Sánchez Migallón, M.V. Gómez Almagro, P. Prieto. Eds. A. de la Hoz, A. Loupy. Wiley (Weinheim) ISBN 3-527-33116-6 (in press).

Application of Flow Chemistry to the Selective Reduction of Esters to AldehydesJ. M. Muñoz, J. Alcázar, A. Diaz-Ortiz; A. de la Hoz.  Eur. J. Org. Chem. 2012, 260-263.

DFT-Studies on Cobalt Catalyzed Cyclotrimerization Reactions. Mechanism and Origin of Reaction Improvement under Microwave IrradiationA.M. Rodriguez, C. Cebrián, P. Prieto, J. I. García, A. de la Hoz, Á. Díaz-Ortiz.   Chem. Eur. J. 2012, 18, 6217-6224

Preparation of amides mediated by isopropylmagnesium bromide under continuous flow conditionsJ.M. Muñoz, J. Alcázar, A. de la Hoz,  A. Díaz-Ortíz, S.-A. Alonso de Diego. Green Chem. 2012, 14, 1335-1341.

Continuous-Flow Microliter Microwave Irradiation in the Synthesis of Isoxazole Derivatives: An Optimization ProcedureA. M. Rodriguez, A. Juan, M. V. Gómez, A. Moreno, A. de la Hoz. Synthesis 2012, 44, 2527-2530


“In silico” mechanistic studies as predictive tools in microwave-assisted organic synthesis.A M Rodriguez, P Prieto, A de la Hoz, A Díaz-Ortiz. Org. Biomol. Chem., 2011, 9, 2371-2377

 Ball Milling modification of Single-Wall Carbon Nanotubes: purification, cutting and functionalizationN. Rubio, C. Fabbro, M. A. Herrero, A. de la Hoz, M. Meneghetti, J. L. G. Fierro, M. Prato, E. Vázquez. Small, 2011, 7, 665-674

Influence of Polarity on the Scalability and Reproducibility of Solvent-Free Microwave-Assisted ReactionsÁ. Diaz-Ortiz, A. de la Hoz, J. R. Alcazar,  J. R. Carrillo, M. Herrero, A. Fontana,  J. M. Munoz, P. Prieto, A. de Cozar. Comb. Chem. High Throughput Screen., 2011, 14, 2, 109-116.

Comparative Study of the Thermal and Microwave Oxidation in Olive Oil. 31p-Nmr Quantitative Determination Of 1,2 And 1,3-Diglycerides And Other Minor Compounds.C. Lucas-Torres, M. Moreno, A. Juan, A. de la Hoz, A. Moreno. Magnetic Resonance in Food Science: An Exciting Future. 2011, 52, 100-104. RSC.

Reproducibility and Scalability of Microwave Assisted Reactions: From Domestic ovens to Continuous Flow Systems.J. Alcázar, A. de Cózar, A. de la Hoz, A. Díaz-Ortiz, J. R. Carrillo, M. A. Herrero, J. M. Muñoz, P. Prieto. Microwave Heating ISBN 978-953-307-325-5. InTech. 2011, 137-162.

Substitution Reactions in Green Chemistry. A. de la Hoz, A. Díaz-Ortiz. Handbook of Green Chemistry. Oxford University Press. in press.

Application of Flow Chemistry to the Reduction of Nitriles to Aldehydes.J. de Mata Muñoz, J. Alcázar, A. Diaz-Ortiz; A. de la Hoz. Tetrahedron Lett., 2011, 52, 6058-6060

Few-layer graphenes using melamine and ball milling processing.V.  León, M. Quintana, M. A. Herrero, J. L. G. Fierro, A. de la Hoz, M. Prato, E. Vázquez. Chem. Commun., 2011, 47, 10936-10938

Electrochemical synthesis and spectroelectrochemical characterization of triazole/thiophene conjugated polymersF. Montilla,  F. Huerta, D. Salinas-Torres, E. Morallón, C. Cebrián, P. Prieto, Á. Díaz-Ortiz, A. de la Hoz, J.R. Carrillo, C. Romero.  Electrochim. Acta. 201158, 215-222.


Microwave-Assisted Stille Reactions as a Powerful Tool for Building Polyheteroaryl Systems Bearing a (1H)-1,2,4-Triazole Moiety.  C Cebrián, A de Cózar, P Prieto, A Díaz-Ortiz, A de la Hoz, JR Carrillo, AM Rodriguez, F Montilla. Synlett (2010) pp. 55-60

Computational calculations in microwave-assisted organic synthesis (MAOS). Application to cycloaddition reactions. A De Cózar, M. C Millán, C Cebrián, P Prieto, A Díaz-Ortiz, A De La Hoz, F. P Cossío.  Org. Biomol. Chem. (2010) vol. 8 (1000) pp. 1009

On-line monitoring of a microwave-assisted chemical reaction by nanoliter NMR-spectroscopy. M Gomez, H. Verputten, A. Diaz-Ortiz, A. Moreno, A. de la Hoz, A. Velders. Chem. Commun.  (2010) vol. 46 (25) pp. 4514-4516

Microwave-assisted synthesis of pyrazolyl bistriazines. M. Moral, A. Ruiz, A. Moreno, A. Diaz-Ortiz, I. Lopez-Solera, A. de la Hoz, A. Sanchez-Migallon.  Tetrahedron (2010) vol. 66 (1) pp. 121-127

Versatile microwave-induced reactions for the multiple functionalization of carbon nanotubes. N. Rubio, M Herrero, A. de la Hoz, M. Meneghetti, M. Prato, E. Vazquez. Org. Biomol. Chem. (2010) vol. 8 (8) pp. 1936-1942

Synergy between microwave irradiation and heterogeneous catalysis in an environmentally friendly self-condensation of hydroxybenzene derivatives M Gomez, A. Moreno, E. Vazquez, A. de la Hoz, A. Aranda, A. Diaz-Ortiz.  ARKIVOC (Gainesville, FL, U. S.) (2010) (3) pp. 264-273



Los estudios de posgrado en química sostenible en España A. de la Hoz, Educación Química, 2009, 405-411

Microwave-Controlled Preparation of Alkenyl-(1H)-1,2,4-triazoles: First Heck Reaction on a (1H)-1,2,4-Triazole Moiety A. Diaz-Ortiz, P. Prieto, A. de Cozar, C. Cebrian, A. Moreno, A. de la Hoz. Aust. J. Chem. 2009, 62, 1600-1606.

Microwave-assisted reactions of nitroheterocycles with dienes. Diels-Alder and tandem hetero Diels-Alder/[3,3] sigmatropic shift. V. Gomez, A. Aranda, A. Moreno, F. Cossio, A. de Cozar, A. Díaz-Ortiz, A. de la Hoz, P. Prieto. Tetrahedron 2009, 65, 5328-5336.


Multiple hydrogen bonds in the self-assembly of aminotriazine and glutarimide. Decisive role of the triazine substituents B. Manzano, F. Jalón, M. Soriano, A. Rodriguez, A. de la Hoz, A. Sanchez-Migallon. Cryst. Growth Des. (2008) vol. 8 (5) pp. 1585-1594

Una orientación de la Química para el Siglo XXI A. de la Hoz, Á. Díaz-Ortiz. Química Sostenible. Mapfre Seguridad 2008, 110, 32-42

Anion-Dependent Self-Assembly of Silver(I) and Diaminotriazines to Coordination Polymers: Non-Covalent Bonds and Role Interchange between Silver and Hydrogen Bonds. B. Manzano, F. Jalón, M. Soriano, M. Carrion, M. Carranza, K. Mereiter, A. Rodriguez, A. de la Hoz, A. Sánchez-Migallón.  Inorg. Chem. 2008, 47, 8957-8971.

Selectivity under microwave irradiation. Benzylation of 2-pyridone: an experimental and theoretical study A. de la Hoz, M. Prieto, M. Rajzmann, A. de Cozar, A. Diaz-Ortiz, A. Moreno, F. Cossio. Tetrahedron 2008, 64, 8169-8176.

Contact info: / Avda. Camilo José Cela, 10 – 13071 Ciudad Real / Web: /

Tfno. 926295411 / Fax: 902 204 130

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