José Miguel Mateo González

José Miguel Mateo González was born the 24th June of 1991 in Valdepeñas (Ciudad Real). He studied Chemical Engineering (2009-2014) at the University of Castilla-La Mancha (UCLM), receiving a Collaboration Internship in order to develop the project titled ‘Microencapsulation of PCMs for Medium Temperature Applications’, his first contact with investigation.

He complemented his academical background studying a Master Degree in Investigation in Chemistry (2014-2015). Meanwhile, he received a UCLM Fellowship to begin his PhD in the Department of Inorganic, Organic and Biochemistry of the UCLM under the supervision of Dra. María Victoria Gómez Almagro (UCLM), with the collaboration of Rosa Mª Sánchez Donoso (UCLM) and Dr. Aldrik Velders (University of Wageningen).

One of the aims of the project is to increase the sensitivity of the Nuclear Magnetic Resonance (NMR) technique reducing the volume of the sample with microchips employed as microreactors. That permits on-line monitoring of reactions (in-situ detection of the intermediates, to know the reaction pathways, etc). Another aim is to introduce the photochemistry as a method to increase the sensitivity by means of Dynamic Nuclear Polarization (DNP), so that the behaviour of certain aminoacids in the surface of some proteins could be studied.

Taking into account these considerations, he developed his Master Degree´s project titled ‘In-situ irradiation of NMR microcoils with UV-Visible light’, in which it has been proved that planar microcoils present broad-band behaviour and both 1D and 2D homo-/hetero-nuclear experiments can be performed. Also irradiation inside the NMR magnet was proved, reaching higher yields in photochemical reactions by means of continuous flow and in-situ irradiation.

From the beginning of his PhD until now, he has acquired a lot of skills in the NMR, flow continuous technique and photochemistry. He has studied the mechanism of the formation of noble metal nanoparticles by NMR with both batch and continuous flow methodologies. Besides that, he has synthesized some precursors for potential pharmaceutical applications combining continuous flow and photochemistry techniques. Finally, he made an international stay at the University of Regensburg with the Dr. Ruth M. Gschwind for the study of the conformational change of peptides when stimulating by light.



Contact information: // Avda. Camilo José Cela, 10 – 13071 Ciudad Real // Telephone Number.: 926295300 Ext. 96345

%d bloggers like this: