History

Microwave and Sustainable Organic Chemistry group

Projects

Our group, Microwaves and Sustainable Organic Chemistry has focused our research in the application of enabling and environmentally benign techniques in Organic Synthesis, microwave activation for organic reactions and the synergy with solvent-free reactions and catalysis.
Our contributions have been reflected in:

(i) Publication of more than 100 papers in international journals dealing with the application of microwave irradiation in organic synthesis, most of them in Q3.

(ii) Edition of various book chapters in the series

Targets in Heterocyclic Systems, Recent Research and Developments in Organic & Bioorganic Chemistry.

Microwaves in Organic Synthesis, (first, second and third Ed. Wiley).  Editor of the third edition.

Activation of Organic Reactions by Microwaves, in the series Advances in Organic Chemistry – Online (Bentham Science Publications).

Microwaves in Green and Sustainable Chemistry. In Environment, Energy and Climate change I: Environmental Chemistry of Pollutants and WastesThe Handbook of Environmental Chemistry. (Springer)

Microwave Assisted Green Chemistry. In  Alternative Energy Sources for Green Chemistry. Green Chemistry Series. RSC.

(iii) Publication of reviews:

Cycloaddition under microwave irradiation (Eur. J. Org. Chem.)

Improvements of Microwave Assisted Organic Synthesis, published in (Contemporary Org. Synth.)

Modifications of the selectivity under microwave irradiation (Current Org. Chem.)

Thermal and non-thermal microwave effects (Chem. Soc. Rev.) with more than 1000 citations to date, being the second most cited review in MAOS.

(iv) Two revisions of our research in this field published by invitation in J. Microwave Power & Electromagnetic Energy y Comb. Chem. & High Throughput Screening.

(v) Participation in the expert board of the Carbon Trust foundation, related to the assignment of funds to industrial projects related to the reduction of carbon emissions.

(vi) Editor of the third edition of the book Microwaves in Organic Synthesis (Wiley, published in 2011-12).

We have imparted Invited Lectures in meetings in Microwave Chemistry, Heterocyclic Chemistry, Green Chemistry and Materials Chemistry, for example, COST action on Reactions under Extreme and Non Classical Conditions (Chambéry, 1996), 2nd and 3rd International Conference on Microwave Chemistry (Prague, 1998 y Antibes, France 2000), 4th Green Chemistry Conference (Barcelone, 2002), Green Chemistry meeting (Barcelone, 2003), VIII Semana científica “Antonio González” (La Laguna, 2004), 3rd Microwave in Chemistry Conference (Orlando, 2005), 10th Internacional Conference on Microwave and High Frequency Heating (Modena, Italia, 2005), First Avogadro Symposium on Microwave Chemistry (Bergamo, Italia, 2005) (only eighteen specialized researchers on applications of microwave irradiation in chemistry were invited), Transmediterranean Colloquium on Heterocyclic Chemistry (TRAMECH-4). (Aveiro, Portugal, 2005), 50th anniversary of the Sociedad Mexicana de Química (Mexico D., 2006), First Congreso Mexicano de Química sustentable (Mérida, 2008) and 216th Meeting of the Electrochemical Society. Viena (Austria).

We have participated in International Scientific Committees in Congresses related to our research, for example: 2nd Internacional Conference on Microwave Chemistry (Praga, 1998), 5th Green Chemistry Conference (Barcelona, 2003), 8th International Electronic Conference on Synthetic Organic Chemistry (2004), 10th International Conference on Microwave and High Frequency Heating (Modena, Italia, 2005).

Our contribution in Microwave Assisted Organic Synthesis can be summarized in:

a) The results obtained by conventional heating have dramatically improved. Improved yields and shortened reaction times were observed.

b) Wide series of compounds with potential interest as ligands in Coordination Chemistry, or with application in Chemistry of materials and Supramolecular Chemistry have been prepared.

c) The design and development of new microwave instruments with higher power that the commercially available and cavities, and new glassware and methods under microwave irradiation and solvent-free conditions.

d) The design and application of used new flow systems coupled to NMR microcoils.

e ) The utility of solid supports under microwave irradiation have made evident with our research.

f) The utility of microwave irradiation in order to modify the selectivity of some reactions have been described.

g) We have used computational calculations to study microwave assisted reactions and we have developed a predictive model that can be used to predict when a reaction will be improved under microwave irradiation by thermal or non-thermal effects.

h) A methodology for the modification of carbon nanostructures under microwave irradiation have been designed, the excellent absorption of microwave radiation and the subsequent chemical activation have been shown.

i) Functionalization of carbon nanostructures with dendrimers under microwave irradiation has been applied with success to the preparation of compounds used in gene transfection.

Two of our researchers have been awarded with prizes, Premio Joven Investigadora “Ibn Wafid de Toledo“ 2009 form the Junta de Comunidades de Castilla-La Mancha and L’Oreal-UNESCO “For Women in Science” 2010.

We have developed collaborations with several groups related to the different subjects of our research. These collaborations are reflected in joint projects, publications and visits by researchers to our laboratories or foreign laboratories. Some of the will participate in some parts of this project. These areas include:

Microwave Assisted Organic Chemistry and Green Chemistry

Dr. Kappe. University of Graz (Austria). Microwave effects.
– Dr. Lahred. University of Uppsala (Sweden) and Dr. Kappe. University of Graz (Austria). Medicinal Chemistry and fluorous chemistry.
Dr. Varma. Environmental Protection Agency (USA) and Dr. Miranda. UNAM (México). Green Chemistry.

Reactions with supports and cycloaddition reactions

Dr. Mayoral (Universidad de Zaragoza). Supported Lewis acids.
Dr. Corma (Instituto de Tecnología Química CSIC-UPV). Zeolites as catalysts in cycloaddition reactions.
Dr. Silva (Universidade de Aveiro. Portugal). Cycloadditions of Styryl chromones.

Supramolecular and Chemistry of Materials

Dr. Elguero (Instituto de Química Médica, C.S.I.C.). Supramolecular structures of 1,3,5-triazines by hydrogen bonding and coordination.
– Drs. Jalón and Manzano (Dpt. Química Inorgánica. Universidad de Castilla-La Mancha). Coordination chemistry.

Dr. Sánchez (Universidad Complutense). Characterization of amphiphilic systems.

Dr. Montilla, (Universidad de Alicante). Electropolimerization of heterocyclic systems.

Dr. Barberá, (Universidad de Zaragoza). Characterization of liquid crystals.

– Dr. Strasser, (Unversity of Münster). Synthesis of Platinum complexes. Photophysical studies.

– Dr. Otero, (Universidad de Castilla-La Mancha). Ccomplexes heteroescorpionate with Aluminium.

Dr. Urriolabeitia, (Universidad de Zaragoza-CSIC). Photocicloaddition in flow.

Fullerenes and nanotubes.

Dr. Langa, Facultad del Medio Ambiente. Universidad de Castilla-La Mancha.
Dr. Prato. Universitá de Trieste.
Dr. Kostarelos. Imperial College de Londres. Pharmaceutical applications of carbon nanotubes.

Photophysical studies

Dr. Guldi. University of Erlangen Photophysics of carbon nanotubes.

Computational Studies:

Dr. Cossío (Universidad del País Vasco) and Dr. Rajzmann (Université de Marseille). Non-thermal microwave effects.
Dr. García Laureiro (Universidad de Zaragoza) Cycloaddition reactions using supported catalysts.
Dr. Alkorta (Instituto de Química Médica, C.S.I.C.) Supramolecular interactions through hydrogen

– Dr. Rajzmann de la Universidad de Marsella sobre cálculos sobre efectos de la radiación microondas en la selectividad.

Structural Determination:

Dr. Claridge (University of Oxford). Structural determination of organic compounds by NMR.
Dr. Velders. (University of Twente). Design of microcoils for NMR and applications on flow chemistry and microwaves.

Flow Chemistry:

Dr. Baxendale. University of Cambridge. Applications of microwave irradiation in flow chemistry.

Collaborations with private companies:

JANSSEN-CILAG, S.A. (Dr. Alcázar). Compatibility, reproducibility and scale up in MAOS.
ALTER, S.A. and ALGRY QUÍMICA, S.A. Preparation of pharmaceutical products.
– ORGANON. Non-thermal microwave effects.
RYMSA and Bunsen, S.A. Development of microwave technology for MAOS.
MICRONIT MICROFLUIDICS (Holland). Design of microcoils for NMR and microreactors
SAIREM. Design and modificaction of microwave instruments.

– AGILENT TECHNOLOGIES. Optimization of NMR probes.

 

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