Photochemically Induced Negishi Coupling in Flow without Photocatalyst

A New Approach to Photosensitizer-free Photocatalysis protocol in flow for the Negishi cross-coupling with an extended scope and improved yields. The scope in the photochemical reaction vs. thermal reaction, which clearly highlights the importance of light for this transformation. This is the first report describing the behavior of organozinc reagents under irradiation. Moreover, the performed … Continue reading

Microchips and Real-Time Photochemical Reaction Monitoring

In a paper published in analítical Chemistry (https://pubs.acs.org/doi/10.1021/acs.analchem.7b04114) we describe a small-volume nuclear-magnetic-resonance (NMR)-spectroscopy device with integrated fiber-optics for the real-time detection of UV–vis-light-assisted chemical reactions. The system with 25 nL detection volumen in an NMR chip, use LEDs or a Laser diode and permits an efficient light penetration.

Microfluidics and Photo-CIDNP

We have shown that the sesibility of NMR can be enhaced untill unprecedent limits with a self-designed and buld technology. This increase in sensibility is higher to tthe described with comercial systems and suposes an rebirth of the photo-CIDNP NMR methodology. Thesse results have been done with NMR microcoils, designed in our group and low  Watts … Continue reading