New Photoinduced Palladium-Catalyzed Negishi Cross-Coupling

In a collaboration between Janssen-UCLM a new Photoinduced Palladium-Catalyzed Negishi Cross-Couplings Enabled by the Visible-Light Absorption of Palladium–Zinc Complexes was described. The scope of deactivated aryl halides employed in the Negishi coupling was significantly expanded. NMR experiments confirmed that the formation of the palladium–zinc complex is key for accelerating the oxidative addition step. Advertisements

Photochemically Induced Negishi Coupling in Flow without Photocatalyst

A New Approach to Photosensitizer-free Photocatalysis protocol in flow for the Negishi cross-coupling with an extended scope and improved yields. The scope in the photochemical reaction vs. thermal reaction, which clearly highlights the importance of light for this transformation. This is the first report describing the behavior of organozinc reagents under irradiation. Moreover, the performed … Continue reading