Photochemically Induced Negishi Coupling in Flow without Photocatalyst

A New Approach to Photosensitizer-free Photocatalysis protocol in flow for the Negishi cross-coupling with an extended scope and improved yields. The scope in the photochemical reaction vs. thermal reaction, which clearly highlights the importance of light for this transformation. This is the first report describing the behavior of organozinc reagents under irradiation. Moreover, the performed mechanistic studies support that light accelerates the reduction of the light absorbing Ni(II) species into Ni(0) by a zincate. This paper adds another very synthetically useful method to the growing area of exogenous photosensitizer-free photocatalysis

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