• UCLM – Organic Microwave Chemistry

  • Our broader area of expertise include Microwave Chemistry, Heterocyclic Chemistry, Computational Chemistry and more recently we have expanded into Nano Chemistry (nanotubes, graphene, etc..) NMR Foods Analysis, and Chemistry-on-flow.

    Contact purposes: Prof. Antonio de la Hoz Ayuso

    Organic Chemistry Professor
    Avda. Camilo José Cela, 10 – 13071 Ciudad Real
    Web: www.umsoc.com / www.uclm.es Tfno. 926295411

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Welcome to the Microwave and Sustainable Organic Chemistry web site

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New Photoinduced Palladium-Catalyzed Negishi Cross-Coupling

In a collaboration between Janssen-UCLM a new Photoinduced Palladium-Catalyzed Negishi Cross-Couplings Enabled by the Visible-Light Absorption of Palladium–Zinc Complexes was described. The scope of deactivated aryl halides employed in the Negishi coupling was significantly expanded. NMR experiments confirmed that the formation of the palladium–zinc complex is key for accelerating the oxidative addition step.

Photochemically Induced Negishi Coupling in Flow without Photocatalyst

A New Approach to Photosensitizer-free Photocatalysis protocol in flow for the Negishi cross-coupling with an extended scope and improved yields. The scope in the photochemical reaction vs. thermal reaction, which clearly highlights the importance of light for this transformation. This is the first report describing the behavior of organozinc reagents under irradiation. Moreover, the performed … Continue reading

Microchips and Real-Time Photochemical Reaction Monitoring

In a paper published in analítical Chemistry (https://pubs.acs.org/doi/10.1021/acs.analchem.7b04114) we describe a small-volume nuclear-magnetic-resonance (NMR)-spectroscopy device with integrated fiber-optics for the real-time detection of UV–vis-light-assisted chemical reactions. The system with 25 nL detection volumen in an NMR chip, use LEDs or a Laser diode and permits an efficient light penetration.

Microfluidics and Photo-CIDNP

We have shown that the sesibility of NMR can be enhaced untill unprecedent limits with a self-designed and buld technology. This increase in sensibility is higher to tthe described with comercial systems and suposes an rebirth of the photo-CIDNP NMR methodology. Thesse results have been done with NMR microcoils, designed in our group and low  Watts … Continue reading

New Flow procedure for the preparation and reactions of organomagnessium reagents

JANSSEN S. A. and MSOC group have reported in Org. Let. a new procedure for the preparation of highly pure organomagnessium reagents on demand and the use in flow and/or batch.

Modulation of the exfoliated graphene work function through cycloaddition of nitrile imines

After the feasibility of the 1,3-dipolar cycloaddition reaction between nitrile imines and exfoliated graphene by density functional theory calculations was proved, very few-layer graphene was effectively functionalized using this procedure. Hydrazones with different electronic properties were used as precursors for the 1,3-dipoles, and microwave irradiation as an energy source enabled the reaction to be performed … Continue reading

Computational Calculations in Microwave-Assisted Organic Synthesis (MAOS). Application to Cycloaddition Reactions.

Computational calculations represent a very useful tool to study separately the ocurrence of thermal and non-thermal effects of microwave irradiation through the determination of the thermodynamic and kinetic parameters of the reaction. In this paper, we approach the computational study of two previously reported cycloaddition reactions. All of the outcomes indicate the presence of a … Continue reading

Review paper on poly(1H-pyrazol-1-yl)methanes

A new revier paper has been published in Coord. Chem. Rev. on the organic chemistry of poly(1H-pyrazol-1-yl)methanes. The synthesis, reactivity, and nature of the coordinated metals are described along with some properties of these compounds, particularly the complete set of X-ray molecular structures.

An article of the group elected as cover in a special issue on Flow Chemistry

A paper on the Reformatsky and Blaise reaction in Flow in collaboration with JANSSEN, S.A. has been published in a special issue of Green Chemsitry on Flow chemistry and has been elected as the cover of the issue.

Network of excellence on NMR

The MSOC by means of Dr. Mª Victoria Gómez Almagro participates in the network of excellence project “Thematic network on NMR spectroscopy”. This is a project with the participation of 10 laboratories in Spain and with a multidiscilplinar and international approach.